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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: May 8, 2026

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

Elevated serum sortilin reflects inflammatory burden and coagulation dysfunction in ulcerative colitis.

Jiangtao Ding1, Haizhou Xu2

  • 1Department of Gastroenterology, Nantong Second People's Hospital, Chongchuan District, Nantong, Jiangsu, China.

Frontiers in Medicine
|May 7, 2026
PubMed
Summary
This summary is machine-generated.

Serum sortilin levels are elevated in ulcerative colitis (UC) patients and correlate with disease activity and inflammation. This suggests sortilin may be a novel biomarker for UC, reflecting inflammatory and hypercoagulable states.

Keywords:
biomarkercoagulationcytokinesinflammationsortilinulcerative colitis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Biochemistry

Background:

  • Sortilin, a receptor involved in inflammatory signaling, has an unclear clinical role in ulcerative colitis (UC).
  • Understanding sortilin's role may offer new insights into UC pathogenesis and potential therapeutic targets.

Purpose of the Study:

  • To investigate serum sortilin levels in UC patients.
  • To assess the association between sortilin levels and UC disease activity, inflammation, and coagulation status.

Main Methods:

  • Serum sortilin, inflammatory cytokines, and coagulation markers were measured in UC patients and healthy controls.
  • Patients were categorized by disease activity and severity.
  • Correlations and diagnostic accuracy (ROC analysis) of sortilin were evaluated.

Main Results:

  • Serum sortilin was significantly higher in UC patients, especially those with active disease, and increased with severity.
  • Sortilin levels positively correlated with inflammatory markers (CRP, TNF-α, IL-1β, IL-6, IL-17A) and coagulation indices (fibrinogen, D-dimer).
  • Sortilin demonstrated high diagnostic accuracy for UC detection and severity assessment.

Conclusions:

  • Elevated serum sortilin is linked to disease activity and inflammation in UC.
  • Sortilin may serve as a novel biomarker for UC, indicating both inflammatory and hypercoagulable states.
  • Further research into sortilin's role could inform UC management strategies.