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Fibrinogen promotes acute myelogenous leukemia progression via miR-486/GPR153 axis

Ming Yang1, Xiaofang You2, Fan Zhao3

  • 1State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Engineering Research Center of Gene Technology (Ministry of Education), Fudan University, Shanghai 200031.

Haematologica
|May 7, 2026
PubMed
Summary

Fibrinogen accelerates acute myeloid leukemia (AML) progression by upregulating miR-486-5p, targeting GPR153 and activating the mTORC2/AKT pathway. This discovery offers new therapeutic targets for AML treatment.

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