Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Gluteal compartment syndrome].

Ugeskrift for laeger·2025
Same author

Persistent postoperative pain after inguinal hernia repair in relation to occupational lifting and standing/walking: a 6-month follow-up study.

Occupational and environmental medicine·2019
Same author

Inguinal hernia repair among men in relation to occupational mechanical exposures and lifestyle factors: a longitudinal study.

Occupational and environmental medicine·2017
Same author

Molecular and biochemical investigations of patients with intermediate or severe hyperhomocysteinemia.

Molecular genetics and metabolism·2016
Same author

Impact of occupational mechanical exposures on risk of lateral and medial inguinal hernia requiring surgical repair.

Occupational and environmental medicine·2012
Same author

Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures--a systematic review of the epidemiologic evidence.

Scandinavian journal of work, environment & health·2012

Related Experiment Video

Updated: May 8, 2026

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy
08:50

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy

Published on: June 25, 2013

[Anesthesia for obese patients].

Lærke Dam Dengsøe Petersen1, Jannie Tanderup Sørensen1, Marie Vestergaard Vad1

  • 1Bedøvelse og Operation Syd, Aarhus Universitetshospital.

Ugeskrift for Laeger
|May 7, 2026
PubMed
Summary

Managing general anesthesia in obese patients presents unique challenges due to altered physiology. This review outlines key perioperative considerations for anesthesiologists to ensure patient safety and optimize outcomes.

Area of Science:

  • Anesthesiology
  • Obesity Medicine
  • Perioperative Care

Background:

  • Obesity is a growing global health concern.
  • Obese patients exhibit significant physiological alterations affecting respiratory, circulatory, and metabolic systems.
  • These physiological changes pose unique challenges in anesthesia management.

Purpose of the Study:

  • To review perioperative anesthesiological perspectives for general anesthesia in obese patients.
  • To synthesize information from primary literature, international guidelines, and enhanced recovery after surgery (ERAS) recommendations.
  • To provide essential knowledge for healthcare professionals managing obese patients undergoing anesthesia.

Main Methods:

  • Literature review.
  • Analysis of international anesthesia guidelines.

More Related Videos

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
05:18

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Published on: November 22, 2024

Related Experiment Videos

Last Updated: May 8, 2026

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy
08:50

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy

Published on: June 25, 2013

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
05:18

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment

Published on: November 22, 2024

  • Inclusion of enhanced recovery after surgery (ERAS) recommendations.
  • Main Results:

    • Obese patients experience altered respiratory mechanics, cardiovascular function, and metabolic processes.
    • These alterations lead to increased risks during general anesthesia and the postoperative period.
    • Specific anesthetic techniques and monitoring strategies are crucial for managing obese patients.

    Conclusions:

    • Anesthesiologists must be aware of the physiological changes in obese patients.
    • Standardized approaches based on current guidelines and ERAS principles are recommended.
    • Enhanced knowledge and preparedness are vital for safe and effective perioperative care of obese individuals.