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Related Experiment Video

Updated: May 8, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Reducing Variability in Deep Gray Matter QSM Using Differential ROI Referencing: A Phantom and In Vivo Evaluation.

Tae Hyun Hwang1, Gawon Lee2,3, Myung Kyun Woo2

  • 1AIRS Medical, Seoul, Republic of Korea.

NMR in Biomedicine
|May 7, 2026
PubMed
Summary

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A new differential reference method for quantitative susceptibility mapping (QSM) improves accuracy in deep gray matter analysis. This technique reduces variability, enhancing the detection of neurodegenerative disease differences in Parkinson's patients.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Quantitative susceptibility mapping (QSM) measures tissue magnetic susceptibility.
  • Susceptibility values are relative, necessitating referencing to mitigate variability.
  • Deep gray matter analysis in neurodegenerative diseases requires robust QSM referencing.

Purpose of the Study:

  • To validate a differential region of interest (ROI) reference method for QSM.
  • To assess the method's feasibility and robustness in deep gray matter analysis.
  • To evaluate its utility in detecting group differences in Parkinson's disease (PD).

Main Methods:

  • Digital phantom and in vivo studies were conducted.
  • Differential ROI referencing was applied to QSM data.
Keywords:
Parkinson's diseaseQSMbrain QSMmagnetic resonance imagingmagnetic susceptibility mappingreference ROIsubstantia nigrasusceptibility

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Last Updated: May 8, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
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Published on: November 27, 2019

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Published on: July 28, 2013

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  • Statistical analysis (ANOVA, FDR-BH) compared PD patients and controls.

    • Main Results:

    • The differential ROI method showed stable susceptibility estimates in phantoms.
    • In vivo, referenced QSM values revealed consistent, significant group differences between PD patients and controls.
    • Unreferenced QSM values exhibited greater variability.

    Conclusions:

    • The differential ROI reference method reduces QSM variability from acquisition and processing.
    • This approach offers a practical, pathology-resilient referencing strategy for deep brain analysis.
    • It shows promise for neuroimaging studies of neurodegenerative diseases.