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Chuanxin Zhang1, Hanjie Xiao1, Xue Jiang1,2

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Summary
This summary is machine-generated.

Researchers developed an integrated ultrasonic platform for closed-loop bioelectronic systems. This technology enables precise deep-tissue targeting and artifact-free feedback for advanced ultrasonic brain-machine interfaces (uBMIs).

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Area of Science:

  • Bioelectronic Systems
  • Ultrasonic Neuromodulation
  • Medical Device Engineering

Background:

  • Closed-loop bioelectronic systems offer transformative potential for neurological and cardiac disorders.
  • Current methods struggle with deep-tissue targeting, artifact-free feedback, and wireless power/data transfer for ultrasonic brain-machine interfaces (uBMIs).
  • Existing technologies limit the realization of adaptive stimulation and precise control in bioelectronic therapies.

Purpose of the Study:

  • To engineer an integrated ultrasonic platform overcoming limitations in deep-tissue targeting, physiological feedback, and wireless operation for uBMIs.
  • To demonstrate high-resolution multifocal ultrasound energy delivery through biological barriers like the skull.
  • To enable adaptive stimulation and robust wireless power and data transfer for closed-loop bioelectronic systems.

Main Methods:

  • Developed a physics-constrained metasurface design framework for high-resolution multifocal ultrasound.
  • Engineered a dual-channel acoustic link for simultaneous wireless power and data streaming through the skull.
  • Demonstrated adaptive stimulation using attention-based and cardiac-synchronized paradigms.

Main Results:

  • Achieved improved experimental targeting accuracy with ±6.5% intensity uniformity across multiple foci through aberrating barriers.
  • Successfully demonstrated continuous wireless power and data streaming via a single acoustic metasurface, robust to a 400-fold power differential.
  • Validated adaptive stimulation capabilities in distinct physiological feedback scenarios.

Conclusions:

  • The integrated ultrasonic framework provides precise spatial targeting through biological barriers, adaptive feedback, and untethered operation.
  • This platform is a significant advancement for next-generation ultrasonic brain-machine interfaces (uBMIs).
  • The developed technology contributes to the advancement of closed-loop bioelectronic therapies for neurological and cardiac disorders.