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Inflammatory Prognostic Index May Predict the Development of Contrast-Induced Nephropathy in Patients with ST-Segment

Yusuf Can1, Emre Eynel2, Şevval Özdemir2

  • 1Department of Cardiology, Sakarya University School of Medicine, Turkey.

Angiology
|May 7, 2026
PubMed

Insights

The inflammatory prognostic index (IPI) effectively predicts contrast-induced nephropathy (CIN) in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). IPI shows superior performance over other inflammation markers for CIN risk assessment.

Area of Science:

  • Cardiology
  • Nephrology
  • Inflammation markers

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI).
  • Predictive models for CIN are crucial for timely intervention and improved patient outcomes.
  • Inflammation-based indices are increasingly recognized for their prognostic value in cardiovascular diseases.

Purpose of the Study:

  • To evaluate the predictive performance of inflammation-based indices for CIN development in STEMI patients undergoing pPCI.
  • To specifically assess the utility of the inflammatory prognostic index (IPI) in predicting CIN.
  • To compare the discriminative performance of IPI against other established inflammation markers.

Main Methods:

  • Retrospective analysis of 563 STEMI patients undergoing pPCI.
  • Calculation and comparison of admission inflammation-based indices: IPI, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein-to-albumin ratio (CAR), and systemic immune inflammation index (SII).
  • Multivariate logistic regression and receiver operating characteristic (ROC) curve analysis to determine independent predictors and discriminative performance.

Main Results:

  • CIN developed in 15.1% of patients.
  • Admission IPI was significantly higher in patients who developed CIN (10.9 vs 4.8, P < .001).
  • IPI independently predicted CIN (OR 1.31, P = .013) and demonstrated superior discriminative performance (AUC 0.826) compared to NLR (AUC 0.691), CAR (AUC 0.712), and SII (AUC 0.704).
  • An IPI cutoff of 8.35 predicted CIN with 82.4% sensitivity and 65.9% specificity.

Conclusions:

  • The inflammatory prognostic index (IPI) is a superior predictor of contrast-induced nephropathy (CIN) in STEMI patients undergoing pPCI.
  • IPI offers better discriminative ability for CIN risk compared to NLR, CAR, and SII.
  • Utilizing IPI may aid in identifying high-risk patients for CIN and guiding preventative strategies.

Keywords:
ST-segment elevation myocardial infarctioncontrast-induced nephropathyinflammatory prognostic indexprimary percutaneous coronary intervention

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