Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrating Inflammation and Lipid Metabolism Biomarkers for Early Risk Stratification in Acute Cerebral Infarction:

Mei Ding1, Jie Dai1, Zhiyong Cao1

  • 1Department of Neurology, Nantong First People's Hospital, Nantong, Jiangsu, China, nt2191.com.

Mediators of Inflammation
|May 7, 2026
PubMed
Summary

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction Value of High Serum Pentraxin-3 for Short-Term Recurrence of Cerebral Infarction in Patients Accompanied with Intracranial Atherosclerotic Stenosis Within One Year.

International journal of general medicineยท2024
See all related articles

Biomarkers like the homocysteine-to-HDL cholesterol (Hcy/HDL-C) and hs-CRP-to-albumin (hs-CRP/Alb) ratios predict poor outcomes in acute cerebral infarction (ACI) patients after rt-PA treatment. A nomogram using these ratios improves prognostic accuracy for personalized risk assessment.

Area of Science:

  • Neurology
  • Biomarkers
  • Cardiovascular Research

Background:

  • Acute cerebral infarction (ACI) poses significant disability risks.
  • Predicting functional outcomes post-thrombolysis is crucial for patient management.
  • Novel biomarkers are needed to enhance prognostic accuracy.

Purpose of the Study:

  • To evaluate the prognostic value of Hcy/HDL-C and hs-CRP/Alb ratios in ACI patients receiving rt-PA.
  • To develop and validate a predictive nomogram for functional outcomes.

Main Methods:

  • Retrospective analysis of 204 ACI patients treated with rt-PA.
  • Classification of patients based on 3-month modified Rankin Scale (mRS) scores.
  • Logistic regression, restricted cubic spline analysis, and nomogram development incorporating Hcy/HDL-C, hs-CRP/Alb, NIHSS, and atrial fibrillation.
Keywords:
Hcy/HDL-Cacute cerebral infarctionhigh-sensitivity C-reactive protein/albumin ratiohs-CRP/Albintravenous thrombolysisprognosis

Related Experiment Videos

Main Results:

  • Elevated Hcy/HDL-C and hs-CRP/Alb ratios independently predicted poor functional outcomes (p < 0.05).
  • The developed nomogram achieved high predictive performance (C-index=0.936, AUC=0.935), outperforming traditional models.
  • Hcy/HDL-C was more predictive in large-artery atherosclerosis, while hs-CRP/Alb was more predictive in cardioembolic stroke subtypes.

Conclusions:

  • Hcy/HDL-C and hs-CRP/Alb ratios are valuable independent predictors of poor outcomes in ACI patients post-rt-PA.
  • The nomogram offers superior prognostic accuracy for personalized risk assessment and management.
  • These biomarkers aid in optimizing thrombolytic therapy strategies.