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Related Experiment Video

Updated: May 8, 2026

Iterative Bleaching Extends Multiplicity with Use of Staining Automation for Core Facilities

Iterative Bleaching Extends Multiplicity with Use of Staining Automation for Core Facilities

Published on: August 6, 2025

A role for core facilities in improving research rigour.

Alison J North¹, Kurt I Anderson²

¹Rockefeller University, New York, New York, USA.

Journal of Microscopy

|May 7, 2026

Summary

Core facility staff play a crucial role in ensuring scientific reproducibility by leveraging their expertise in training, quality control, and institutional knowledge. Their oversight enhances research integrity and efficiency, often overlooked by traditional reproducibility discussions.

Keywords:

best practice core facility light microscopy quality control reproducibility rigour training

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Last Updated: May 8, 2026

Iterative Bleaching Extends Multiplicity with Use of Staining Automation for Core Facilities

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Published on: September 27, 2024

Area of Science:

Life Sciences
Biotechnology
Scientific Research Infrastructure

Background:

Scientific reproducibility is a key ethical and societal responsibility.
Discussions on reproducibility often overlook the vital role of core facility staff.
Core facilities act as institutional memory, guiding researchers and preventing unproductive approaches.

Purpose of the Study:

To review existing core facility practices that support scientific reproducibility.
To suggest additional opportunities for core facility staff to enhance their role in promoting scientific excellence.
To highlight the often-underestimated contribution of core facilities to research integrity.

Main Methods:

Review of current best practices in core facilities, particularly in light microscopy.
Analysis of how core facility operations align with recommendations for improving reproducibility.
Identification of areas where core facilities can further contribute to reproducibility.

Main Results:

Many core facility best practices, such as instrument quality control and rigorous training, inherently support reproducibility.
Core facilities can improve statistical robustness through enhanced awareness and education.
Core facility staff possess unique functions in research planning, training, interpretation, and oversight that directly impact reproducibility.

Conclusions:

Core facility staff are essential guardians of scientific excellence and reproducibility.
Expanding the role of core facilities in reproducibility efforts is critical for scientific integrity.
The principles discussed for light microscopy facilities are broadly applicable to other technology-focused core facilities.