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A Case of GLP-1 Receptor Agonist-Induced Dysphoria and Aggression in a Patient With Underlying Major Depressive
Mia Hofstad1, Izabella De Abreu
1Department of Psychiatry, The University of Texas Southwestern Medical Center Medical School, Dallas, TX.
Abstract:
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have recently emerged as a promising therapeutic option for patients to aid in weight loss; however, little is known about the potential psychiatric side effects of these medications. In this report, we present the case of a 64-year-old man who was started on the GLP-1 RA tirzepatide (Zepbound) and subsequently developed increased impulsivity, dysphoria, and aggression, which resolved with medication cessation. We suggest a potential relationship between GLP-1 RAs and mood, and we caution physicians to weigh the potential risks of the medications against the known benefits.
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