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Updated: May 8, 2026
08:18
Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions.
Jian Deng1, Ruipu Sun1, Zhiyong Bai1
1Department of Targeting Therapy and Immunology and Laboratory of Cell Engineering and Immunotherapy, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Aging
|May 7, 2026
Summary
Cellular senescence research is shifting from static identification to understanding functional roles. A new strategy proposes preventing harmful senescence and precisely intervening in existing senescent cells to promote healthspan.
Area of Science:
- Cellular Biology
- Aging Research
Background:
- Cellular senescence research traditionally focused on identifying senescent cells using markers like p16 and β-galactosidase.
- Emerging evidence highlights the functional heterogeneity and physiological roles of senescent cells in development and tissue repair.
Purpose of the Study:
- To review senescence induction mechanisms and functional phenotype evolution.
- To propose a novel "prevention first, precision intervention" paradigm for senescence management.
Main Methods:
- Literature review of senescence induction and functional evolution.
- Proposal of a management strategy based on functional profiling and targeted intervention.
Main Results:
- Senescent cells exhibit diverse functional roles, not all being detrimental.
- A proposed strategy involves preventing detrimental senescence and selectively targeting maladaptive senescent cells.
Conclusions:
- A shift towards understanding senescence function is crucial.
- The proposed paradigm offers a safer, more effective approach to preventing age-related diseases and extending healthspan.
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