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Updated: May 8, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Sinonasal ameloblastoma: Clinical case presentation and literature review]
Francisco Javier Martínez-Fernández1, Fany Gabriela Juárez-Aguilar1
1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Anatomía Patológica. Ciudad de México, México.
Background:
Sinonasal ameloblastoma is considered a locally benign, rare, and locally aggressive neoplasm. It is included within the so-called peripheral ameloblastomas. The symptoms are nonspecific, such as epistaxis, rhinorrhea, and nasal obstruction. The diagnosis requires a broad approach, imaging studies and complete clinical history; however, the histopathological diagnosis is the gold standard. As for treatment, the mainstay is surgical; however, it is currently being studied to complement it with radiotherapy or BRAF inhibitors. The objective was to present a clinical case of a Mexican patient, as well as to make a bibliographic review of the subject.
Clinical Case:
Woman originally from and resident of Mexico City who began with hearing loss, rhinorrhea, and nasal obstruction. Imaging studies revealed a mass that completely occupied the right maxillary sinus and the ipsilateral nasal cavity. The pathology study revealed that it was an ameloblastoma.
Conclusions:
Although rare, the described case presented the clinical characteristics described in the international literature, and even though there are no standardized guidelines for the treatment of this entity, appropriate treatment was provided in accordance with international recommendations for these cases.
