Related Experiment Video
Updated: May 9, 2026
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Increased Extracolonic Cancer Incidence and Mortality in Patients with Serrated Polyposis Syndrome with a History of
Yasutsugu Shimohara1, Hidehiko Takigawa2, Yuji Urabe1
1Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Introduction:
Serrated polyposis syndrome (SPS) is a high-risk factor for colorectal cancer (CRC); however, prognostic differences based on patient characteristics are poorly understood. This exploratory study investigated the impact of concomitant or a history of CRC at the time of SPS diagnosis on long-term prognosis.
Methods:
Of the 70 patients diagnosed with SPS between 2009 and 2023, 55 with a 1-year follow-up were included in this single-center retrospective cohort study. Patients with a history of CRC were assigned to the CRC (+) (n = 16) group and those without a history of CRC were assigned to the CRC (-) group (n = 39). We compared the baseline characteristics, surveillance findings, and long-term outcomes, including new extracolonic cancer incidence and overall survival, between the groups.
Results:
The CRC (+) group had a significantly higher prevalence of personal history of other cancers (38% vs. 10%, p = 0.024) and family history of cancer (69% vs. 38%, p = 0.048). The incidence of new extracolonic cancers during follow-up after the diagnosis of SPS was significantly higher in the CRC (+) group (25%; 4/16) than in the CRC (-) group (3%; 1/39) (p = 0.012). Overall survival was also significantly poorer in the CRC (+) group (two deaths, 13%) than in the CRC (-) group (p = 0.044).
Conclusion:
A history of CRC in patients with SPS is associated with a higher incidence of new extracolonic cancer and poorer overall survival. These findings suggest that management strategies should extend beyond standard colorectal surveillance to comprehensive systemic monitoring. Therefore, the validation of these results in larger prospective cohorts is warranted.
Related Concept Videos
01:27Diverticular Disease of the Colon
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...