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Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

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Updated: May 9, 2026

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
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Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

Quorum-sensing-responsive materials: Toward living smart interfaces in biomedical systems.

Santosh Pandit1, Demet Erdönmez2, Duygu Polat2

  • 1Systems and Synthetic Biology Division, Department of Life Sciences, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.

Advances in Colloid and Interface Science
|May 7, 2026
PubMed
Summary

Smart materials sensitive to bacterial communication (quorum sensing) offer new ways to diagnose infections early and deliver targeted treatments. These innovative platforms can help combat antibiotic resistance and improve patient care.

Keywords:
Bacteria-responsive materialsBiomedical applicationsLiving materialsQuorum sensingSmart interfaces

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Bridging the Bio-Electronic Interface with Biofabrication
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Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

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Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
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Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

Bridging the Bio-Electronic Interface with Biofabrication
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Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Antimicrobial Development

Background:

  • Quorum sensing (QS) is a bacterial communication system regulating virulence and biofilm formation.
  • Traditional biomaterials are passive and lack dynamic infection-response capabilities.
  • Emerging smart materials can sense and respond to QS signals.

Purpose of the Study:

  • To review the clinical significance of QS-sensitive materials.
  • To outline mechanism-driven design principles for these smart materials.
  • To discuss translational challenges and future potential.

Main Methods:

  • Leveraging bacterial communication molecules (acylhomoserine lactones, autoinducer peptides).
  • Designing materials to detect QS thresholds linked to virulence or biofilm.
  • Integrating QS detection with therapeutic outputs like drug release or surface modification.

Main Results:

  • QS-sensitive materials enable early detection of pathogenic activity.
  • These materials can trigger targeted antimicrobial release and modulate host responses.
  • Dynamic "living" interfaces offer infection-specific effects with reduced systemic exposure.

Conclusions:

  • QS-sensitive materials represent a significant advancement in infection diagnosis and therapy.
  • They hold potential for addressing antibiotic resistance and improving patient outcomes.
  • These platforms support precision infection control in healthcare settings.