Tranexamic acid-grafted hyaluronic acid hemostatic powder for rapid hemostasis and wound healing

Achieving rapid hemostasis and effective wound healing remains a crucial clinical challenge. Herein, hyaluronic acid (HA) grafted with tranexamic acid (TXA) was prepared as a novel hemostatic material (HA-TXA), which showed rapid hemostatic activity and promoted wound healing. When HA-TXA interacted with blood in vitro, hemostasis was achieved within 30 s, and a stable blood clot was formed by promoting red blood cell and platelet adhesion as well as inhibiting fibrin degradation. Furthermore, in vivo experiments demonstrated that HA-TXA could greatly decrease the bleeding time and blood loss, besides, HA-TXA could also promote collagen deposition and achieve the wound healing rate of about 98% within 14 days, showing significantly better efficacy than the commercial products (Yunnan Baiyao and Celox). Collectively, HA-TXA may be a promising candidate for next-generation hemostats, with great potential in trauma care and emergency medicine.