Emerging lipids-based adjuvant delivery technologies for vaccines

Area of Science:

• Vaccinology
• Biomaterials Science
• Immunology

Background:

• Infectious disease pandemics necessitate effective vaccination strategies.
• Next-generation vaccines utilize advanced platforms like nucleic acids and protein subunits.
• Adjuvants are crucial for enhancing vaccine efficacy, stability, and safety.

Purpose of the Study:

• To review the development and evaluation of lipids-based delivery platforms serving as vaccine adjuvants.
• To provide an overview of literature on lipids-based adjuvant delivery systems for vaccine applications.
• To serve as a reference for scientists in vaccine product development.

Main Methods:

• Literature review of open-source publications.
• Analysis of lipids-based particulate systems (emulsions, micro/nanoparticles, liposomes).
• Evaluation of their role in delivering vaccine modalities and enhancing immune responses.

Main Results:

• Lipids-based systems are promising, flexible choices for adjuvant delivery.
• Particulate lipids-based systems facilitate delivery to antigen-presenting cells (APCs).
• These systems enable nucleic acid translation and protein synthesis for vaccine efficacy.

Conclusions:

• Lipids-based adjuvant delivery platforms are integral to modern vaccine development.
• Their tunable nature allows for tailored delivery of diverse vaccine modalities.
• Further research into these systems will advance vaccine product development and pandemic preparedness.