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Updated: May 9, 2026
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Published on: November 25, 2013
First In-vivo Human Magnetic Particle Imaging
Patrick Vogel1,2, Thomas Kampf1,3, Martin Andreas Rückert1
1Julius-Maximilians University, Department of Experimental Physics 5 (Biophysics), Germany, Würzburg.
Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|May 7, 2026
Summary
First-in-human magnetic particle imaging (MPI) angiography successfully visualized veins in real-time without radiation. This radiation-free imaging modality showed comparable results to conventional angiography, paving the way for clinical applications.
Area of Science:
- Medical Imaging
- Biomedical Engineering
- Radiology
Background:
- Magnetic Particle Imaging (MPI) is an emerging tracer-based imaging technique.
- MPI offers radiation-free visualization with high temporal resolution.
- Previous in-vivo human applications of MPI have not been reported.
Purpose of the Study:
- To demonstrate the feasibility of the first in-human MPI angiography.
- To compare MPI angiography with conventional X-ray digital subtraction angiography (DSA).
Main Methods:
- A first-in-human MPI angiography was performed on a healthy volunteer.
- A human-scale interventional MPI scanner and ferucarbotran tracer were used.
- Imaging was conducted under clinical conditions, with DSA performed for comparison.
Main Results:
- MPI successfully visualized major superficial and deep veins, including inflow, branching, valves, and collateral pathways.
- The spatial and temporal resolution of MPI was comparable to DSA.
- No adverse events were reported during the procedure.
Conclusions:
- First in-vivo human MPI angiography is feasible.
- MPI provides real-time, radiation-free angiographic visualization.
- MPI shows potential for selected vascular and interventional clinical applications.
