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Free light chain EQA: Analytical variability with clinical consequences - Data from 25 Italian EQA exercises

Fabio Pasotti1, Simona Da Molin1, Tiziana Bosoni2

  • 1Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 7, 2026
PubMed
Summary

Serum free light chain (FLC) assays show significant differences between methods, impacting monoclonal gammopathy diagnosis. Harmonized interpretation requires method-specific reference intervals and standardization pending international consensus.

Keywords:
External quality assessmentFree light chainsLaboratory harmonisationMethod comparisonκ/λ ratio

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