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Related Experiment Video

Updated: May 9, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
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Published on: August 21, 2021

Doxycycline release from cyclodextrin oligomer-containing collagen gels.

Eric Trout1, Leena Palomo2, Horst A von Recum1

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 7, 2026
PubMed
Summary

Cyclodextrin oligomers incorporated into collagen gels significantly enhance drug release, increasing the releasable amount of doxycycline by 220% and reducing its release rate fivefold for improved therapeutic delivery.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Collagen hydrogels offer a promising matrix for localized drug delivery but often exhibit rapid drug release.
  • Developing strategies to control drug release kinetics from collagen matrices is crucial for effective therapeutic applications.
  • Chronic peri-implantitis necessitates improved treatment strategies, including localized, sustained antibiotic delivery.

Purpose of the Study:

  • To investigate the incorporation of soluble cyclodextrin oligomers into collagen hydrogels.
  • To evaluate the impact of cyclodextrin oligomers on the release kinetics of doxycycline from collagen matrices.
  • To explore the potential of this system for treating chronic peri-implantitis.

Main Methods:

  • Fabrication of native D-banded collagen fibril hydrogels.
  • Incorporation of soluble γ-cyclodextrin (CD) oligomers during collagen fibrillogenesis.
  • Loading and in vitro release studies of doxycycline from collagen-CD hydrogels.
  • Mathematical modeling to differentiate matrix and CD effects on drug release.

Main Results:

  • Incorporation of CD oligomers increased the releasable amount of doxycycline by 220%.
  • The release rate of doxycycline from collagen-CD hydrogels was reduced fivefold compared to controls.
  • Affinity-based interactions between doxycycline and CD oligomers significantly altered release kinetics.

Conclusions:

  • Soluble cyclodextrin oligomers can be effectively incorporated into collagen hydrogels to modulate drug release.
  • This affinity-based material design offers a strategy for prolonged drug delivery, even in diffusion-dominated systems.
  • The developed collagen-CD hydrogel system shows potential for simplified clinical management of chronic peri-implantitis through localized, sustained doxycycline delivery.