Doxycycline release from cyclodextrin oligomer-containing collagen gels.

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Collagen hydrogels offer a promising matrix for localized drug delivery but often exhibit rapid drug release.
• Developing strategies to control drug release kinetics from collagen matrices is crucial for effective therapeutic applications.
• Chronic peri-implantitis necessitates improved treatment strategies, including localized, sustained antibiotic delivery.

Purpose of the Study:

• To investigate the incorporation of soluble cyclodextrin oligomers into collagen hydrogels.
• To evaluate the impact of cyclodextrin oligomers on the release kinetics of doxycycline from collagen matrices.
• To explore the potential of this system for treating chronic peri-implantitis.

Main Methods:

• Fabrication of native D-banded collagen fibril hydrogels.
• Incorporation of soluble γ-cyclodextrin (CD) oligomers during collagen fibrillogenesis.
• Loading and in vitro release studies of doxycycline from collagen-CD hydrogels.
• Mathematical modeling to differentiate matrix and CD effects on drug release.

Main Results:

• Incorporation of CD oligomers increased the releasable amount of doxycycline by 220%.
• The release rate of doxycycline from collagen-CD hydrogels was reduced fivefold compared to controls.
• Affinity-based interactions between doxycycline and CD oligomers significantly altered release kinetics.

Conclusions:

• Soluble cyclodextrin oligomers can be effectively incorporated into collagen hydrogels to modulate drug release.
• This affinity-based material design offers a strategy for prolonged drug delivery, even in diffusion-dominated systems.
• The developed collagen-CD hydrogel system shows potential for simplified clinical management of chronic peri-implantitis through localized, sustained doxycycline delivery.