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Published on: October 26, 2017

Circulating miR-483-5p predicts long term all-cause mortality in hospitalized older adults

Silvia Di Valerio1, Deborah Ramini2, Matilde Sbriscia2

  • 1Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.

Mechanisms of Ageing and Development
|May 7, 2026
PubMed

Insights

Predicting mortality in older adults is hard. Higher levels of circulating microRNA-483-5p (miR-483-5p) in hospitalized seniors were linked to a greater risk of 10-year all-cause mortality.

Area of Science:

  • Gerontology and Aging Research
  • Molecular Biology and Genetics
  • Biomarkers and Diagnostics

Background:

  • Predicting long-term mortality in older adults is challenging, as chronological age and clinical factors do not fully capture biological vulnerability.
  • Circulating microRNAs (miRNAs) are emerging biomarkers for aging, but their long-term prognostic utility needs further definition.

Purpose of the Study:

  • To investigate the association between selected circulating microRNAs and 10-year all-cause mortality in hospitalized older adults.
  • To determine if specific microRNAs can serve as biomarkers for biological vulnerability and predict mortality risk in late life.

Main Methods:

  • Prospective observational study within the Report-AGE cohort involving 648 hospitalized adults aged ≥65 years.
  • Measurement of baseline circulating levels of miR-483-5p, miR-320b, miR-21-5p, and miR-146a-5p, categorized into tertiles.
  • Survival analysis using Cox models, adjusted for multiple clinical and demographic factors, with a median follow-up period leading to 525 deaths.

Main Results:

  • Higher circulating levels of miR-483-5p were significantly associated with increased 10-year all-cause mortality risk.
  • This association remained robust after adjusting for numerous confounders and excluding individuals with chronic kidney disease.
  • miR-483-5p and miR-320b showed stronger correlations with Phenotypic Age acceleration than chronological age, suggesting a link to biological aging.

Conclusions:

  • Circulating miR-483-5p is a potential biomarker associated with increased mortality risk in older adults.
  • miR-483-5p may reflect underlying biological vulnerability beyond chronological age and clinical status.
  • These findings suggest miR-483-5p could improve mortality prediction and understanding of aging pathophysiology.
Keywords:
MiR-320bMiR-483–5pMicroRNAMortalityOlder patients

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