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Updated: May 9, 2026
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Separation of Avian Preovulatory Follicle Granulosa and Theca Cell Layers for Downstream Applications
Published on: October 25, 2024
Dynamic expression pattern and regulatory network of circRNAs during chicken ovarian development
Yihan Liu1, Zhiyuan An1, Jingqi Wang1
1College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Genomics
|May 7, 2026
Summary
This study identifies key circular RNAs (circRNAs) involved in chicken ovarian development and egg-laying performance. These findings reveal novel regulatory mechanisms for reproductive efficiency in poultry.
Area of Science:
- Reproductive Biology
- Genomics
- Poultry Science
Background:
- Circular RNAs (circRNAs) are vital in mammalian reproduction, but their role in chicken reproduction is largely unknown.
- Understanding circRNA regulation is crucial for improving chicken ovarian development and egg-laying performance.
Purpose of the Study:
- To investigate the regulatory roles of circRNAs in chicken ovarian development across the egg-laying cycle.
- To identify key circRNAs and their potential mechanisms in regulating folliculogenesis and egg production.
Main Methods:
- Time-course transcriptome profiling of chicken ovarian tissues.
- Identification and characterization of circRNAs, including those with translation potential.
- Differential expression analysis, co-expression network analysis, and pathway enrichment analysis.
Main Results:
- 6551 circRNAs were identified, with 1556 showing translation potential.
- 1894 differentially expressed circRNAs (DE-circRNAs) displayed stage-specific patterns and were linked to follicular development pathways.
- 136 co-expressed DE-circRNAs were identified as key candidates regulating ovarian development.
Conclusions:
- Circular RNAs play significant regulatory roles in chicken ovarian development and egg-laying performance.
- Key circRNAs may regulate folliculogenesis-related genes via the competitive endogenous RNA (ceRNA) mechanism.
- This research provides insights into the molecular mechanisms underlying poultry reproduction.
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