Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A probiotic BL53 enhances the immunomodulatory and neurorestorative activities of red ginseng in cyclophosphamide-exposed mice through the transformation of ginsenosides to compound K.

Journal of applied microbiology·2026
Same author

Qingfei Huatan Formula alleviates growth suppression and inflammation-driven metabolic dysregulation in avian infectious bronchitis virus-infected broilers.

Poultry science·2026
Same author

Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same author

Cognitive functions of the GPe.

Trends in neurosciences·2026
Same author

Immunometabolic Reprogramming by Black Soldier Fly (<i>Hermetia illucens</i>) Lipids in Monogastric Nutrition: From Receptor Crosstalk to the "Immune-Energy Sparing" Effect.

Animals : an open access journal from MDPI·2026
Same author

Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles.

Biological cybernetics·2026
Same journal

Cortical and thalamic afferent connectomes distinguish ACC subregions of the macaque brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Speakers with cerebellar ataxia do not adapt speech segment durations in response to durationally altered auditory feedback.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The precision of hippocampal representations predicts incremental value-learning across the adult lifespan.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Dynamic Sensorimotor Behavior Reveals Bayesian Belief Updating.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Evolving Roles of Primary Cilia in CNS Development and Neural Circuit Function: From Human Disease to Molecular Underpinnings.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles
  1. Home
  3. Ih Shapes Pathway-specific Inhibition In The Substantia Nigra Pars Reticulata.
  1. Home
  3. Ih Shapes Pathway-specific Inhibition In The Substantia Nigra Pars Reticulata.

Related Experiment Video

The 6-hydroxydopamine Rat Model of Parkinson's Disease
08:10

The 6-hydroxydopamine Rat Model of Parkinson's Disease

Published on: October 27, 2021

Ih Shapes Pathway-Specific Inhibition in the Substantia Nigra Pars Reticulata.

Ya E Gao1,2, Xiaoyang Ma3, Jianan Jian2,4

  • 1Neuroscience Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 7, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

The substantia nigra pars reticulata (SNr) receives inhibitory inputs that are tuned by hyperpolarization-activated currents (Ih). This interaction shapes inhibitory efficacy differently for external globus pallidus and striatal pathways, impacting movement control.

Keywords:
GPeIhSNrbasal gangliainhibitionsynaptic

More Related Videos

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

Related Experiment Videos

The 6-hydroxydopamine Rat Model of Parkinson's Disease
08:10

The 6-hydroxydopamine Rat Model of Parkinson's Disease

Published on: October 27, 2021

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • The substantia nigra pars reticulata (SNr) is crucial for movement control, acting as the basal ganglia's main inhibitory output.
  • GABAergic inputs from the external globus pallidus (GPe) and striatum modulate SNr activity, but their interaction with intrinsic neuronal properties is unclear.

Purpose of the Study:

  • To investigate how GABAergic inputs and intrinsic membrane currents interact to regulate SNr firing.
  • To determine the role of hyperpolarization-activated currents (Ih) in shaping inhibitory efficacy from different pathways.

Main Methods:

  • Optogenetics, electrophysiology, and computational modeling were used in acute mouse brain slices.
  • Measurements were performed on 47 animals of either sex.

Main Results:

  • GPe inputs cause brief SNr inhibition due to fast IPSCs and rapid recovery mediated by Ih.
  • Striatal inputs induce longer SNr pauses due to slower IPSC kinetics that counteract Ih.
  • Blocking Ih with ZD7288 equalized inhibitory efficacy between pathways.

Conclusions:

  • Synaptic kinetics and intrinsic currents (Ih) interact to create pathway-specific inhibitory balance in the SNr.
  • This interplay is a key biophysical mechanism regulating basal ganglia output and movement control.