Long-Term Wound Healing Dynamics and Tissue Remodeling After Minimally Invasive Voice Preservation Techniques...

Minimally invasive voice-preservation techniques, including microlaryngoscopy, phonosurgery, and office-based regenerative interventions, have revolutionized the management of benign and early-stage laryngeal disorders by minimizing fibrosis and preserving phonatory function. However, the long-term (>6 months) wound healing and extracellular matrix (ECM) remodeling dynamics that determine sustained vocal outcomes remain poorly understood, particularly among professional singers who experience high vibratory demand. Moreover, African American and minority singers continue to face significant barriers to specialty laryngology care, underrepresentation in research cohorts, and disparities in insurance coverage, creating inequities in both access and postoperative outcomes. This review synthesizes evidence on chronic wound healing and ECM remodeling following minimally invasive voice-preservation procedures, emphasizing histologic integration, molecular mediators of fibrosis, and correlations with objective (dysphonia severity index, vocal extent measure, and maximum phonation time) and subjective (voice handicap index, singing voice handicap index) recovery metrics. It also examines racial and socioeconomic inequities in laryngeal care among professional voice users. Our method for this research was to use PubMed, JStor, Web of Science, and Cochrane Library databases starting from 2000. The study will include randomized controlled trials and observational cohorts and case series with ten or more patients and previous systematic reviews that focus on wound healing and functional outcomes and access disparities. Two reviewers will conduct independent screening and data extraction, while thematic synthesis will be used to organize existing evidence and identify areas where more research is needed. Existing studies demonstrate consistent short-term improvement in acoustic and perceptual metrics but limited histologic data beyond 9-12 months. Available human biopsy findings reveal fibroblast infiltration and partial ECM integration (eg, silk-hyaluronic acid hydrogels, adipose-derived stromal vascular fraction therapy), yet lack quantitative analysis of collagen I/III ratios, elastin content, and viscoelastic restoration. Professional singers remain largely excluded from histologic or biomechanical cohorts. Persistent racial and geographic disparities further limit access to specialized voice-preservation surgery and longitudinal follow-up. Long-term remodeling after minimally invasive voice-preservation procedures remains underexplored, with crucial gaps in linking tissue biomechanics to clinical outcomes and health equity. This review identifies priorities for multicenter, demographically inclusive research integrating molecular, histologic, and performance-based endpoints to advance equitable, evidence-based voice care for professional singers and high-demand voice users.