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Chitosan-Based Powder with Ultrafast Powder-Gel Transition for Accelerated Hemostasis and Enhanced Tissue

You Zhou¹, Yunjin Li^2,3, Zhengkai Han¹

¹Beijing Jishuitan Hospital, Capital Medical University, Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, PR China.

Langmuir : the ACS Journal of Surfaces and Colloids

|May 7, 2026

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A novel chitosan/poly(acrylic acid) composite powder effectively stops severe bleeding from noncompressible wounds. This advanced hemostatic agent promotes tissue regeneration and offers a promising solution for emergency settings.

Area of Science:

Biomaterials Science
Trauma Management
Wound Healing

Background:

Uncontrolled post-traumatic bleeding, particularly from noncompressible wounds, is a leading cause of mortality.
Current hemostatic powders have limitations including poor clot stability, tissue adhesion, and biocompatibility.

Purpose of the Study:

To develop and evaluate a novel chitosan (CS)/poly(acrylic acid) (PAA) composite hemostatic powder (CP powder) for managing noncompressible bleeding.
To assess the hemostatic, biocompatibility, and tissue regeneration properties of the CP powder.

Main Methods:

The CP powder was synthesized by dehydrating and grinding a CS/PAA hydrogel.
In vitro assessments included fluid absorption, gelation time, antibacterial efficacy, hemocompatibility, immunoregulation, and coagulation performance.

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In vivo studies evaluated hemostasis in noncompressible wounds and immune microenvironment modulation.

Main Results:

The CP powder rapidly absorbed fluids and formed a hydrogel in situ within 10 seconds.
Demonstrated excellent antibacterial, hemocompatible, immunomodulatory, and pro-coagulant properties in vitro.
Achieved rapid hemostasis in noncompressible wounds and promoted tissue regeneration in vivo.

Conclusions:

The developed CP powder offers effective and rapid hemostasis for severe bleeding.
It exhibits potential for enhanced tissue regeneration, addressing limitations of current hemostatic agents.
This composite powder presents a promising strategy for clinical and emergency trauma care.