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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: May 9, 2026

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls
10:16

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls

Published on: January 4, 2018

HuR coordinates systemic aging through platelet infiltration.

Cihang Liu1,2, Ying Wang2, Tianjiao Xia3

  • 1Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Nature Communications
|May 7, 2026
PubMed
Summary
This summary is machine-generated.

Platelets play a central role in systemic aging. Targeting the HuR protein in platelets can reduce inflammation and delay aging across multiple organs.

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Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
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Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

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Related Experiment Videos

Last Updated: May 9, 2026

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls
10:16

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls

Published on: January 4, 2018

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

Area of Science:

  • Gerontology
  • Hematology
  • Molecular Biology

Background:

  • Aging is characterized by organ-specific changes, but the inter-organ connections remain unclear.
  • Platelets, traditionally known for hemostasis, are increasingly recognized for roles beyond blood clotting.

Purpose of the Study:

  • To investigate the role of platelets in systemic aging.
  • To identify molecular mechanisms linking platelets to age-related changes across organs.

Main Methods:

  • Analysis of platelet-secreted pro-inflammatory factors (PSPF) in aged mice.
  • Investigating the function of RNA-binding protein HuR/ELAVL1 in platelet biology.
  • Utilizing platelet-specific HuR deletion models in mice.
  • Employing single-nucleus sequencing to analyze tissue-level molecular changes.

Main Results:

  • Aged mice showed increased PSPF levels and platelet infiltration in multiple organs.
  • HuR/ELAVL1 in platelets promotes PSPF production.
  • Platelet-specific HuR deletion reduced PSPF, alleviated organ infiltration, and delayed systemic aging.
  • HuR ablation in platelets modulated p53 and inflammatory pathways in aged liver, lung, and brain tissues.

Conclusions:

  • Platelets are key mediators of systemic aging, coordinating age-related changes across organs.
  • The HuR/ELAVL1 pathway in platelets is a critical regulator of age-related inflammation and organ dysfunction.