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The multifaceted physiological roles of fungal laccases
Jinyang Li1, Jintong Zhang1, Changyu Pi1
1National Center of Technology Innovation for Synthetic Biology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Abstract:
Fungal laccases are multi-copper oxidases widely studied for biotechnological applications such as lignin valorization and bioremediation. However, their physiological roles in fungal biology remain under-explored. This review synthesizes these essential functions, including melanin biosynthesis for virulence, detoxification of plant antimicrobials, regulation of morphological development, and interspecies interactions. Understanding these native roles is critical for elucidating fungal ecology and pathogenesis, developing targeted antifungal strategies, and optimizing industrial laccase production. By integrating biochemical and multi-omics insights, this review establishes a unified framework centered on laccase functionality to bridge knowledge gaps and identify future research priorities in fungal physiology.
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