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Replacing protein with carbohydrate or fat in infancy is associated with lower Body Mass Index in early childhood:
Tinsae Shemelise Tesfaye1, Ewa A Szymlek-Gay2, Carley A Grimes2
1Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC, Australia. s222395555@deakin.edu.au.
Background:
Higher intakes of total and animal-source protein during infancy have been associated with higher body mass index (BMI) z scores in childhood.
Objective:
We examined the association of substituting protein with fat or carbohydrate intake, and the substitution of protein subtypes at 9 months of age with BMI z-scores and overweight status in children at 5 years of age.
Methods:
This study involved a secondary analysis of data from the Melbourne InFANT program, a 15-month infancy obesity prevention intervention, with additional follow-ups conducted without intervention when children were aged 3.5 and 5 years. Data of 345 children who completed the 9-month, and 5-year follow-ups were analysed. Dietary intake at 9 months was assessed using three 24-h recalls. BMI z-score was measured at 9 months and 5 years of age. Multivariable linear and logistic regression models with adjustment for potential confounders examined the associations between macronutrient and protein subtype substitutions at 9 months and changes in BMI z-score or overweight status at 5 years.
Results:
Substitution of 5%E or 100 kJ protein intake with carbohydrate intake at age 9 months was associated with a 0.16-unit (95% CI: -0.30, -0.02) or 0.11-unit (95% CI: -0.19, -0.03) decrease in BMI z-score at 5 years. Similarly, replacing 5%E or 100 kJ of protein intake with fat intake was associated with a 0.16-unit (95% CI: -0.29, -0.02) or 0.11-unit (95% CI: -0.19, -0.03) decrease in BMI z-score. There was no evidence of an association between substitution of protein with fat or carbohydrate intake and overweight status (P > 0.05). Replacement of animal protein with plant or dairy protein was also not significantly associated with BMI z-score or overweight status.
Conclusions:
Substituting protein with carbohydrate or fat intake in infancy was inversely associated with BMI z-score in early childhood. The present study supports the need to discourage excessive protein intake during infancy.
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