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A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
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Recent advances in the regulation of CD47 by non-coding RNAs and its therapeutic potential in cancer

Jingwen Hua1, Weijin Zhu2, Xiaochun Sun3

  • 1School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu Province, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|May 7, 2026
PubMed

Insights

Non-coding RNAs (ncRNAs) regulate Cluster of Differentiation 47 (CD47) expression, offering a novel immunotherapy approach. Targeting the ncRNA-CD47 axis may overcome limitations of current CD47 antibody therapies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Cluster of Differentiation 47 (CD47) is a key target in cancer immunotherapy, mediating tumor immune escape via the signal regulatory protein alpha (SIRPα) pathway.
  • Current CD47 antibody therapies face challenges including erythrocyte toxicity, antigen sink effect, and clinical trial setbacks.

Purpose of the Study:

  • To systematically review the role of non-coding RNAs (ncRNAs) as upstream regulators of CD47.
  • To explore how targeting the ncRNA-CD47 axis can address limitations of current CD47 immunotherapies.

Main Methods:

  • Systematic review of scientific literature on ncRNA regulation of CD47.
  • Analysis of ncRNA mechanisms impacting CD47 gene expression, phagocytosis, drug resistance, and tumor microenvironment.

Main Results:

  • Non-coding RNAs (miRNAs, lncRNAs, circRNAs) are identified as critical regulators of CD47.
  • The ncRNA-CD47 axis influences key cancer processes including phagocytosis and drug resistance.

Conclusions:

  • Targeting the ncRNA-CD47 axis presents a promising alternative to antibody-based therapies for CD47 immunotherapy.
  • Genetic modulation via ncRNAs offers potential for reduced systemic toxicity and improved therapeutic outcomes in CD47-targeted cancer treatment.
Keywords:
CD47Cancer immunotherapyImmune checkpointNon-coding RNAs (ncRNAs)

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