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Hybrid Biostimulator and Hyaluronic Acid Injectable for Tear Trough Rejuvenation
Stephanie Ming Young1,2, Edmond K H Lau3
1Eagle Aesthetics and Surgery, King Albert Park, Singapore. Stephanieyoung83@gmail.com.
Aesthetic Plastic Surgery
|May 7, 2026
Summary
This study shows poly-D,L-lactic acid-hyaluronic acid (PDLLA-HA) injections effectively correct tear troughs and improve under-eye skin quality. Patients reported high satisfaction with no adverse events, indicating PDLLA-HA is a promising option for non-surgical rejuvenation.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Regenerative Medicine
Background:
- Non-surgical correction of the under-eye region presents unique challenges.
- The tear trough area is particularly difficult to treat effectively.
- Novel injectable biostimulators offer potential solutions for rejuvenation.
Purpose of the Study:
- To evaluate the efficacy and safety of a novel poly-D,L-lactic acid-hyaluronic acid (PDLLA-HA) biostimulator for tear trough correction.
- To assess improvements in under-eye skin quality, including elasticity, hydration, and radiance.
- To determine patient and investigator satisfaction with the treatment outcomes.
Main Methods:
- Prospective cohort study involving patients receiving three PDLLA-HA injections for tear trough correction.
- Outcomes measured using the Global Aesthetic Improvement Scale (GAIS) by both patients and investigators.
- Skin features (elasticity, hydration, quality, radiance) assessed using a subjective scale; patient satisfaction and adverse events were recorded.
Main Results:
- The study included 15 female participants with a mean age of 38.5 years.
- Significant improvements in investigator and patient GAIS scores were observed after each treatment session.
- Marked enhancement in skin elasticity, hydration, quality, and radiance (p<0.001) with no reported adverse events.
- All participants expressed willingness to repeat the treatment.
Conclusions:
- Poly-D,L-lactic acid-hyaluronic acid (PDLLA-HA) is a safe and effective injectable for tear trough correction.
- PDLLA-HA significantly improves under-eye skin characteristics, including elasticity, hydration, quality, and radiance.
- This biostimulator represents a promising option for non-surgical under-eye rejuvenation.
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