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CircPTP4A2 (hsa_circ_0007364) facilitates non-small cell lung cancer progression by regulating miR-127-5p/SMC3

Yali Feng1, Jiang Hong2, Changgang Yang3

  • 1Department of Oncology, Haian People's Hospital, Nantong, China.

Biology Direct
|May 7, 2026
PubMed

Insights

Circular RNA PTP4A2 (circPTP4A2) is elevated in non-small cell lung cancer (NSCLC) and drives tumor growth. Targeting circPTP4A2 may offer new therapeutic strategies for NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality globally.
  • Current diagnostic and therapeutic approaches for NSCLC require improvement.
  • Understanding the molecular mechanisms underlying NSCLC is crucial for developing novel strategies.

Purpose of the Study:

  • To investigate the role of circular RNA PTP4A2 (circPTP4A2) in NSCLC.
  • To explore the potential of circPTP4A2 as a diagnostic marker and therapeutic target.

Main Methods:

  • Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was employed to measure circPTP4A2 expression in NSCLC tissues and adjacent normal tissues from 50 patients.
  • In vitro experiments involved silencing circPTP4A2 in NSCLC cell lines (SPCA1, H1299) to assess its impact on cell proliferation and metastasis.
  • The influence of miR-127-5p and SMC3 modulation on circPTP4A2-induced phenotypic changes was examined.

Main Results:

  • CircPTP4A2 was significantly upregulated in NSCLC tumor tissues compared to adjacent normal tissues.
  • Higher circPTP4A2 expression correlated with poorer patient survival and prognosis.
  • Silencing circPTP4A2 inhibited proliferation and metastatic potential in NSCLC cell lines.
  • Modulation of miR-127-5p and SMC3 expression reversed the effects of circPTP4A2 knockdown.

Conclusions:

  • CircPTP4A2 is oncogenic in NSCLC, promoting tumorigenesis and progression.
  • The miR-127-5p/SMC3 signaling axis is implicated in circPTP4A2-mediated tumor promotion.
  • CircPTP4A2 represents a potential biomarker and therapeutic target for NSCLC.
Keywords:
NSCLCSMC3circPTP4A2circRNAmiR-127-5p

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