Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Exercise and Muscle Performance

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...

Exercise and Cardiac Output

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correlation study between gut microbiota and intestinal permeability in cerebral small vessel disease.

Journal of Alzheimer's disease : JAD·2026

Same author

Effects of combined aerobic and resistance exercise on sarcopenia in elderly patients with type 2 diabetes mellitus.

The Journal of endocrinology·2025

Same author

Fndc5/irisin mediates the benefits of aerobic exercise intervention on aging-associated sarcopenia in mice.

European geriatric medicine·2025

Same author

Effects of Dexmedetomidine Anesthesia on Early Postoperative Cognitive Dysfunction in Elderly Patients.

ACS chemical neuroscience·2022

Same author

Correlation of Lgr5 expression with clinicopathological features of colorectal cancer and its diagnostic and prognostic values.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2021

Same author

Optically pumped NMR oscillator based on <sup>131</sup>Xe nuclear spins.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2021

Search research articles

Related Experiment Video

Updated: May 9, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Regular Daily Exercise Improves Sarcopenia in Elderly Patients.

Jiachuang Zheng¹, Hui Luo², Zhixia Zheng²

¹Health Examination Center, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China.

Rejuvenation Research

|May 8, 2026

Summary

A 12-week exercise program significantly improved daily living activities, muscle mass, strength, and mobility in older adults with sarcopenia. This intervention also reduced systemic inflammation, enhancing overall health and independence.

Keywords:

activities of daily living inflammatory biomarkers multicomponent exercise older adults sarcopenia

More Related Videos

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Related Experiment Videos

Last Updated: May 9, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Area of Science:

Gerontology
Exercise Physiology
Nutritional Science

Background:

Sarcopenia, characterized by loss of muscle mass and strength, significantly impacts independence and mobility in older adults.
There is a critical need for scalable, nonpharmacological interventions to combat sarcopenia and its associated functional decline.

Purpose of the Study:

To evaluate the efficacy of a 12-week multicomponent exercise program on functional independence, muscle health, physical performance, and systemic inflammation in older adults diagnosed with sarcopenia.

Main Methods:

A 12-week randomized controlled trial involving adults aged 60-75 years with sarcopenia.
Participants were assigned to either a control group or an exercise group performing postprandial multicomponent training (resistance and aerobic exercise) 3 days/week.
Primary endpoint was the Modified Barthel Index (MBI); secondary endpoints included Appendicular Skeletal Muscle Mass Index (ASMI), handgrip strength, 6-minute walk test (6MWT), Timed Up and Go Test (TUGT), and inflammatory markers (IL-6, TNF-α).

Main Results:

The exercise group demonstrated significant improvements in MBI, ASMI, and handgrip strength compared to the control group (p < 0.001).
Participants in the exercise group showed enhanced physical performance, evidenced by better 6MWT results and shorter TUGT times (p = 0.005).
The exercise intervention led to a significant reduction in serum IL-6 and TNF-α levels (p < 0.001).

Conclusions:

A 12-week multicomponent exercise program is an effective nonpharmacological intervention for improving functional independence in older adults with sarcopenia.
Regular exercise positively influences muscle mass, strength, mobility, and reduces systemic inflammation, contributing to better overall health outcomes in this population.