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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Published on: July 25, 2020

Precision Oncology: Emerging Molecular Methods for Drug Target Discovery.

Dharmendra Kumar Yadav1, Desh Deepak Singh2, Dongyun Shin1

  • 1College of Pharmacy, Gachon University, Hambakmoeiro 191, Yeonsu-gu, Incheon 21924, Republic of Korea.

Current Topics in Medicinal Chemistry
|May 8, 2026
PubMed
Summary
This summary is machine-generated.

Molecular-targeted cancer therapies block key molecules for tumor growth, offering improved efficacy and fewer side effects. This review covers strategies like angiogenesis inhibition and targeting cell division for innovative cancer medicine development.

Keywords:
Antitumor molecular drugsCancerKinase targetsMolecular targetsSignaling pathwaysTargeted therapies

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Molecular-targeted cancer therapies offer improved efficacy and reduced side effects compared to traditional treatments.
  • These therapies focus on specific molecules crucial for tumor growth and survival.
  • A comprehensive understanding of molecular targets is essential for developing novel anticancer drugs.

Purpose of the Study:

  • To review various molecular-targeted cancer therapy strategies.
  • To explore the conceptual framework guiding the development of innovative anticancer medicines.
  • To highlight key molecular targets and pathways involved in cancer progression and treatment.

Main Methods:

  • Review of existing literature on molecular-targeted cancer therapies.
  • Analysis of different therapeutic strategies including angiogenesis inhibition, microtubule targeting, and signal transduction pathway modulation.
  • Discussion of targets such as transcription factors, growth factors, tumor suppressor genes, and enzymes.

Main Results:

  • Identified multiple molecular targets and pathways crucial for cancer therapy.
  • Detailed various strategies like angiogenesis inhibition, microtubule targeting, and signal transduction modulation.
  • Highlighted the importance of apoptosis induction, metastasis inhibition, and targeting specific enzymes (e.g., COX-2, LOX).

Conclusions:

  • Molecular-targeted therapies represent a significant advancement in cancer treatment.
  • A multi-faceted approach targeting various molecular pathways is key to effective cancer management.
  • Continued research into the conceptual framework of anticancer drug discovery is vital for future innovations.