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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Beyond Gallstones and Alcohol: Unveiling Hypertriglyceridemia as the Cause of Pancreatitis
G K M Rashik Uzzaman1, Monowara Rahman Shipi2, Nusrat Jahan3
1General Medicine, United Lincolnshire Teaching Hospitals NHS Trust, Lincoln, GBR.
Abstract:
Hypertriglyceridemia is a less frequent yet clinically significant cause of acute pancreatitis, accounting for approximately 4-10% of cases, and is often overlooked when routine laboratory analysis is hindered by lipemia-related analytical interference. We describe two cases of severe hypertriglyceridemia-induced pancreatitis presenting with acute abdominal pain and markedly elevated triglyceride levels. The first case involved polygenic hypertriglyceridemia triggered by undiagnosed diabetes. The second case represented secondary, alcohol-related hypertriglyceridemia. In both cases, lipemia-related laboratory interference complicated the initial evaluation, but prompt recognition and treatment with intravenous insulin led to rapid clinical and biochemical improvement. These cases highlight the need for early consideration of hypertriglyceridemia in pancreatitis of unclear etiology, awareness of laboratory artifacts, and prompt triglyceride-lowering therapy to prevent complications.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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