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Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Nirmatrelvir methyl tert-butyl ether solvate
Jared P Smit1, Dale K Purcell1, David A Engers1
1Improved Pharma, LLC, 1281 Win Hentschel Blvd., West Lafayette, IN 47906, USA.
Abstract:
The structure of nirmatrelvir MTBE solvate, C23H32F3N5O4·C5H12O, at 150 K has monoclinic (P21) symmetry. The asymmetric unit contains one nirmatrelvir mol-ecule and one methyl tert-butyl ether solvent mol-ecule. The extended structure consists of N-H⋯O hydrogen bonds that create create [010] chains. Crystals of the title compound were grown from various methyl tert-butyl ether-methanol solvent mixtures, with crystal morphology dependent upon the mixture ratio.
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