Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Issues And Trends In Healthcare Delivery System

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

Arturo Casadevall Speaks on Curiosity, Resilience, and Scientific Integrity.

Pathogens & immunity·2026

Same authorSame journal

Eating Away at Antibiotic Resistance - Is Phage Therapy Our Future?

Pathogens & immunity·2026

Same author

Monocyte Activation in People With HIV and Tuberculosis Coinfection and Effect of Tuberculosis Preventive Therapy: An Analysis of the ACTG A5279/BRIEF TB Trial.

Open forum infectious diseases·2026

Same author

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1.

Science advances·2025

Same author

The effect of low-dose methotrexate on arterial inflammation in persons living with human immunodeficiency virus: A double-blind randomized placebo-controlled pilot trial.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2025

Same author

Dysbiosis modulates CD8<sup>+</sup> tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection.

iScience·2025

Search research articles

Related Experiment Video

Updated: May 9, 2026

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

Published on: December 15, 2023

Eric Topol, MD, Discusses Longevity, AI, and Evidence-Based Medicine.

Michael M Lederman¹, Leonard H Calabrese²

¹Case Western Reserve University, Cleveland, Ohio.

Pathogens & Immunity

|May 8, 2026

Summary

Dr. Eric Topol shares insights from his career in patient-centered medicine and cardiology. He stresses adaptability and staying curious to navigate changes in medicine, especially with artificial intelligence.

Keywords:

Artificial Intelligence in Medicine Evidence-Based Longevity Preventive Medicine Scientific Integrity

More Related Videos

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models

Published on: June 30, 2023

Related Experiment Videos

Last Updated: May 9, 2026

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

Published on: December 15, 2023

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models

Published on: June 30, 2023

Area of Science:

Medical Research
Cardiology
Digital Health

Background:

Dr. Eric Topol's career spans decades in cardiology and patient-centered medicine.
His journey highlights the importance of humanistic mentorship and adaptability in scientific focus.

Purpose of the Study:

To reflect on a career dedicated to patient-centered medical practice.
To discuss the impact of evolving evidence and artificial intelligence on physician-scientists.

Main Methods:

The content is based on an interview with Dr. Eric Topol.
Reflective insights on a career in medicine and scientific inquiry.

Main Results:

Adaptability and responsiveness to new evidence are crucial for physician-scientists.
Artificial intelligence is transforming medical research, publishing, and practice.

Conclusions:

Early-career physician-scientists should remain curious and prioritize patient care.
Maintaining scientific credibility is essential amidst technological advancements in medicine.