Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

CRISPR and crRNAs

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

Global Regulatory Systems

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

CRISPR

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database.

Frontiers in immunology·2025

Same author

Transcending traditional prognostic assessments: Predictive efficacy of MRA-based BATMAN and PCCS scores in basilar artery occlusive stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2025

Same author

Use of thoracic CT values in opportunistic screening for osteoporosis.

Radiologie (Heidelberg, Germany)·2025

Same author

Radiomics and machine learning for osteoporosis detection using abdominal computed tomography: a retrospective multicenter study.

BMC medical imaging·2025

Same author

Prevalence and Risk Factors of Functional Hearing Loss in Chinese Adults: A Cross-sectional Study.

Noise & health·2025

Same author

16S rRNA sequencing-based evaluation of the protective effects of key gut microbiota on inhaled allergen-induced allergic rhinitis.

Frontiers in microbiology·2025

Search research articles

Related Experiment Video

Updated: May 9, 2026

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Research progress on circRNAs in type 2 CRS.

Zhai Liu¹, Zhi Chen¹

¹Department of Otolaryngology Head and Neck Surgery, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital), Changsha, Hunan, China.

Frontiers in Immunology

|May 8, 2026

Summary

This summary is machine-generated.

Circular RNAs (circRNAs) are novel non-coding RNAs regulating gene expression. This study summarizes circRNA mechanisms in type 2 inflammation, distinguishing experimental findings from unvalidated clinical applications for chronic rhinosinusitis.

Keywords:

circRNA diagnosis and treatment molecular sponge post-transcriptional regulation type 2 chronic rhinosinusitis

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Related Experiment Videos

Last Updated: May 9, 2026

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Area of Science:

Molecular Biology
Immunology
Genetics

Background:

Circular RNAs (circRNAs) are non-coding RNAs regulating gene expression.
circRNAs can act as miRNA sponges, inhibiting miRNA activity.
Emerging evidence links circRNAs to type 2 inflammation in chronic rhinosinusitis.

Purpose of the Study:

To systematically summarize circRNA molecular mechanisms in type 2 inflammation.
To differentiate established experimental evidence from potential clinical applications.
To provide a theoretical foundation for future research in type 2 chronic rhinosinusitis.

Main Methods:

Literature review and synthesis of existing research on circRNAs and type 2 inflammation.
Analysis of experimental data regarding circRNA function in immune regulation.
Evaluation of current clinical evidence for circRNA involvement in chronic rhinosinusitis.

Main Results:

circRNAs play diverse roles in gene expression regulation, including miRNA sponging.
Specific circRNAs are implicated in immune cell and cytokine modulation relevant to type 2 inflammation.
Direct clinical evidence linking circRNAs to type 2 chronic rhinosinusitis diagnosis or severity is currently lacking.

Conclusions:

circRNAs represent a significant area of research in understanding type 2 inflammation.
Further research is needed to validate the clinical relevance of circRNAs in chronic rhinosinusitis.
This review provides a framework for future investigations into circRNA-based diagnostics and therapeutics.