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Strengthening regional surveillance: MenMap Network's year 1 findings on bacterial meningitis in Jordan, Egypt, and
Lamia Al-Kershi1, Deema Al Bakri1, Zeina Abdel Majeed1
1Eastern Mediterranean Public Health Network, Amman, Jordan.
Objectives:
Vaccine-preventable invasive bacterial diseases remain a public health concern in the Middle East and North Africa (MENA) region. To address surveillance and diagnostic gaps, the Meningitis and Septicemia Mapping Network (MenMap) was launched as a prospective, multicenter sentinel surveillance system to strengthen laboratory capacity and regional collaboration in Jordan, Egypt, and Iraq. This study reports the first-year MenMap findings (December 2023 to November 2024), describing bacterial meningitis epidemiology, pathogen distribution, vaccination status, clinical presentation, and outcomes among laboratory-confirmed cases in Jordan, Egypt, and Iraq.
Methods:
Prospective sentinel hospital-based surveillance was implemented in 16 hospitals, targeting children aged 1 month to 18 years. Suspected cases were defined according to World Health Organization criteria and included patients presenting with clinical signs of meningitis and undergoing cerebrospinal fluid and/or blood sampling. Standardized protocols included clinical evaluations, real-time polymerase chain reaction for pathogen detection, and continuous monitoring systems. An external quality assessment scheme ensured laboratory diagnostic quality and accuracy.
Results:
Between December 2023 and November 2024, 2104 suspected cases were reported, with 191 (9%) confirmed. S. pneumoniae was the most prevalent (90.0%), followed by H. influenzae (7.9%) and N. meningitidis (2.1%). Most confirmed cases were from Iraq (63.3%), and 62% across the three countries occurred in children aged <5 years.
Conclusion:
MenMap strengthens bacterial meningitis surveillance in the MENA region and provides critical evidence to support vaccine policy decisions, including expansion of pneumococcal and Haemophilus influenzae type b immunization programs, alongside improvements in pathogen detection and characterization.
Insights
The Meningitis and Septicemia Mapping Network (MenMap) enhanced surveillance for bacterial meningitis in the Middle East and North Africa (MENA) region. Streptococcus pneumoniae was the most common pathogen identified in confirmed cases.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Vaccine-preventable invasive bacterial diseases pose a significant public health challenge in the Middle East and North Africa (MENA) region.
- Existing surveillance and diagnostic capabilities for these diseases require enhancement.
Purpose of the Study:
- To establish the Meningitis and Septicemia Mapping Network (MenMap), a prospective, multicenter sentinel surveillance system.
- To strengthen laboratory capacity and regional collaboration for meningitis and septicemia surveillance in Jordan, Egypt, and Iraq.
- To describe the epidemiology, pathogen distribution, and outcomes of laboratory-confirmed bacterial meningitis cases in the first year of MenMap surveillance.
Main Methods:
- Prospective, hospital-based sentinel surveillance was conducted in 16 hospitals across Jordan, Egypt, and Iraq.
- The study targeted children aged 1 month to 18 years presenting with suspected meningitis based on World Health Organization criteria.
- Standardized protocols included clinical evaluations, real-time polymerase chain reaction (PCR) for pathogen detection, and an external quality assessment scheme for laboratory diagnostics.
Main Results:
- A total of 2104 suspected cases were reported between December 2023 and November 2024, with 191 (9%) confirmed cases.
- Streptococcus pneumoniae was the most prevalent pathogen (90.0%), followed by Haemophilus influenzae (7.9%) and Neisseria meningitidis (2.1%).
- The majority of confirmed cases were reported from Iraq (63.3%), with 62% occurring in children under 5 years of age.
Conclusions:
- The MenMap initiative effectively enhances bacterial meningitis surveillance in the MENA region.
- Findings provide crucial evidence to inform vaccine policy, including potential expansion of pneumococcal and Haemophilus influenzae type b immunization programs.
- The surveillance system contributes to improved pathogen detection and characterization, aiding public health interventions.
Related Concept Videos
Bacterial Meningitis I: Introduction
Principles of Disease Surveillance
Investigation of Disease Outbreaks
Bacterial Meningitis II: Pathophysiology
Viral Meningitis
Steps in Outbreak Investigation
