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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: May 9, 2026

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
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Resveratrol for Cancer Radio-Sensitization: Ready for Prime Time or Future Perspective.

Maryam Fallah1,2, Ali Soleimani1, Ali Nouri1

  • 1Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran.

Food Science & Nutrition
|May 8, 2026
PubMed
Summary

Resveratrol shows promise for various diseases due to its antioxidant and anti-inflammatory effects. However, inconsistent clinical results and side effects necessitate further research for safe and effective therapeutic use.

Keywords:
anticancerapoptosisautophagyradiotherapyradio‐sensitizationresveratrol

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Molecular Biology

Background:

  • Resveratrol, a natural polyphenol, exhibits antioxidant and anti-inflammatory properties.
  • Preclinical data suggest therapeutic potential across metabolic, neurological, cardiovascular, and inflammatory diseases.
  • Clinical studies indicate possible benefits in anti-cancer and cardioprotective applications.

Purpose of the Study:

  • To review clinical data on resveratrol's effects on disease biomarkers.
  • To emphasize resveratrol's potential as an adjunct therapy in cancer radiotherapy.
  • To propose a framework for future research to optimize its clinical application.

Main Methods:

  • Review of clinical trial data.
  • Analysis of resveratrol's impact on disease-specific biomarkers.
  • Evaluation of molecular mechanisms including ROS inhibition and NF-κB signaling suppression.

Main Results:

  • Resveratrol modulates oxidative stress and inflammatory pathways (ROS, NF-κB, JAK/STAT).
  • It influences metabolic signaling via AMPK/mTOR pathways.
  • Clinical outcomes are inconsistent, and high doses may cause side effects like gastrointestinal discomfort.

Conclusions:

  • Variability in resveratrol's efficacy and safety necessitates well-designed clinical trials.
  • Further research should focus on standardized methodologies, optimized dosing, and safety evaluations.
  • A structured research framework is proposed to clarify benefits and risks for evidence-based clinical use.