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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Next-Generation Anticancer Peptides: Engineering, Nanotheranostics and Clinical Translation.

Abhishesh Kumar Mehata1, Shinsuke Fukui1, Yoshihiro Izumiya1,2,3

  • 1Department of Dermatology, School of Medicine, University of California, Davis (UC Davis), 3301 C-street, Sacramento, CA 95816, USA.

Nanotheranostics
|May 8, 2026
PubMed
Summary
This summary is machine-generated.

Anticancer peptides (ACPs) are a promising new cancer therapy. Advances in peptide engineering and nanotechnology enhance their stability, targeting, and delivery for improved cancer treatment.

Keywords:
anticancer peptideclinical translationdrug deliverytargeted cancer therapytheranostics

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Area of Science:

  • Oncology
  • Biotechnology
  • Materials Science

Background:

  • Anticancer peptides (ACPs) offer targeted cancer cell selectivity and multifunctional therapeutic capabilities, surpassing conventional chemotherapeutics.
  • Peptide engineering and nanotechnology advancements are crucial for overcoming biological barriers and enhancing ACP efficacy.
  • Current challenges include stability, immunogenicity, manufacturing, and regulatory issues for widespread clinical application.

Purpose of the Study:

  • To review recent advancements in ACP discovery, molecular engineering, and nanotheranostic integration.
  • To highlight strategies for improving ACP stability, potency, and targeted delivery.
  • To outline a future roadmap for peptide-based precision oncology.

Main Methods:

  • Review of current literature on peptide engineering techniques (e.g., sequence optimization, non-natural amino acids, PEGylation).
  • Analysis of nanotechnology platforms (e.g., nanoparticles, stimuli-responsive systems) for ACP delivery.
  • Examination of preclinical and clinical progress of ACPs and theranostic integration.

Main Results:

  • Peptide engineering has significantly improved ACP stability, potency, and pharmacokinetics.
  • Nanotechnology platforms enhance ACP targeting, controlled release, and theranostic capabilities.
  • Emerging strategies like enzyme-activated and stimuli-responsive systems offer precise spatiotemporal control.

Conclusions:

  • Next-generation ACP platforms integrate targeted cytotoxicity, immune activation, and imaging for advanced cancer therapy.
  • Continued research in engineering and nanodelivery systems is vital for realizing the full potential of ACPs in precision oncology.
  • Addressing challenges in stability, immunogenicity, and manufacturing is key to clinical translation.