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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Hyperventilation-Induced High-Amplitude Rhythmic Slowing and Its Impact on Migraine Frequency in Children: A

Mahmoud Mohammadi1,2, Reza Shervin Badv2,3, Zahra Rezaei1,2

  • 1Pediatrics Center of Excellence, Department of Pediatric Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Iranian Journal of Child Neurology
|May 8, 2026
PubMed

Insights

Children with hyperventilation-induced high-amplitude rhythmic slowing (HIHARS) on EEG show increased migraine risk. A family history of migraine further elevates this susceptibility in pediatric patients.

Area of Science:

  • Pediatric Neurology
  • Neurophysiology
  • Headache Disorders

Background:

  • Migraine is the most common primary headache disorder in children.
  • Hyperventilation (HV) can induce high-amplitude rhythmic slowing (HIHARS) on electroencephalogram (EEG) in some children.
  • The link between HIHARS and future migraine development in children requires investigation.

Purpose of the Study:

  • To evaluate the correlation between HIHARS observed during HV maneuvers and the subsequent risk of migraine onset in children.
  • To identify potential predictive markers for pediatric migraine development.

Main Methods:

  • The study included children aged 7-12 undergoing EEG with HV maneuvers.
  • Long-term video-EEG monitoring was used to assess migraine diagnosis based on ICHD-3 criteria after six years.
  • Statistical analysis was performed on clinical and neurophysiological data, including family history and seizure presence.

Main Results:

  • Children exhibiting HIHARS during HV were significantly more likely to develop migraine within six years (P=0.049).
  • A family history of migraine was more prevalent in children with HIHARS (68.18%) compared to those without (40%) (P=0.044).
  • Seizure occurrence did not significantly influence the association between HIHARS and migraine.

Conclusions:

  • This study is the first to demonstrate a correlation between HIHARS and increased migraine susceptibility in children.
  • Pediatric patients aged 7-12 with HIHARS show a heightened risk for developing migraine headaches.
  • Children with HIHARS and a family history of migraine are predicted to have a greater susceptibility to developing migraine later in life.
Abstract

Keywords:
ChildrenEEGHIHARSMigraine

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