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Related Experiment Video

Updated: May 9, 2026

High-Resolution Ultrasonography for the Analysis of Orthotopic ATC Tumors in a Genetically Engineered Mouse Model
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Ultrasound-guided microwave ablation for small thyroid nodules with RAS mutation: a pilot study.

Fengyun Cheng1, Yujiang Li1, Ruixue Huang2

  • 1Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.

Frontiers in Oncology
|May 8, 2026
PubMed
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This summary is machine-generated.

Microwave ablation (MWA) shows promise for treating small RAS-mutated thyroid nodules, achieving significant volume reduction and high regression rates within 24 months. This minimally invasive technique offers a safe and effective option for managing these challenging nodules.

Area of Science:

  • Endocrinology
  • Oncology
  • Minimally Invasive Surgery

Background:

  • RAS-mutated thyroid nodules present clinical management challenges.
  • Effective treatment options for small RAS-mutated nodules are needed.

Purpose of the Study:

  • To evaluate the efficacy and safety of microwave ablation (MWA) for thyroid nodules ≤ 2 cm with isolated RAS gene mutations.

Main Methods:

  • Retrospective study of 23 patients with RAS-mutated thyroid nodules treated with MWA.
  • Follow-up of at least 12 months, collecting data on nodule volume, volume reduction rate (VRR), and adverse events.
  • Statistical analysis including Friedman rank sum test, linear regression, and ROC analysis.

Main Results:

  • At 12 months, median VRR was 11.84% with a 13.0% complete regression rate.
Keywords:
RAS mutationmicrowave ablationnodule volumethyroid nodulevolume reduction rate

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  • By 24 months, median VRR reached 100% with 83.33% complete regression.
  • Nodules < 6 mm showed higher regression rates; no recurrence or metastasis observed.

    • Conclusions:

    • MWA demonstrates favorable short-term efficacy and safety for treating small RAS-mutated thyroid nodules.
    • Sustained nodule shrinkage and high regression rates are achievable with MWA.
    • MWA is a potential minimally invasive treatment for selected RAS-mutated thyroid nodules.