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Updated: May 9, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

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Published on: March 17, 2016

Longitudinal Degeneration of Microstructural and Structural Connectivity Patterns Following Stroke.

Lorenzo Pini1,2, Mohammad Hadi Aarabi2, Alessandro Salvalaggio1,2

  • 1Department of Neuroscience (L.P., A.S., M.C.), University of Padua, Italy.

Stroke
|May 8, 2026
PubMed
Summary
This summary is machine-generated.

White matter (WM) degeneration progresses after stroke, impacting brain networks. While acute changes correlate with deficits, chronic WM alterations seem uncoupled from long-term behavioral recovery.

Keywords:
cognitionconnectomediffusion tensor imagingprognosisworkflow

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Area of Science:

  • Neuroscience
  • Neurology
  • Biomedical Engineering

Background:

  • Stroke induces neurological impairment via plasticity and network reorganization.
  • Post-stroke white matter (WM) remodeling for behavioral recovery remains debated.
  • This study investigates longitudinal WM changes and their link to post-stroke behavior.

Purpose of the Study:

  • To determine if longitudinal changes in WM microstructure and structural connectivity correlate with post-stroke behavior.
  • To explore the relationship between structural connectivity reorganization and local disconnection microstructure.

Main Methods:

  • Prospective cohort study with diffusion MRI and behavioral assessments at 2 weeks and 3 months post-stroke.
  • Latent factorial analysis of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) data.
  • Analysis of structural connectivity, microstructural diffusion parameters, and behavioral factors using linear mixed models and regression.

Main Results:

  • Stroke patients showed diffuse WM alterations at 2 weeks, linked to microstructural abnormalities in disconnected pathways.
  • WM degeneration progressed from 2 weeks to 3 months post-stroke.
  • Acute structural connectivity changes correlated with cognitive deficits; chronic WM degeneration was linked to motor impairment.

Conclusions:

  • Mild stroke causes widespread, progressive WM microstructure alterations that evolve over time.
  • Acute structural disconnection relates to behavioral deficits.
  • Chronic WM degeneration appears uncoupled from functional recovery.