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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Clonal hematopoiesis in lung adenocarcinoma pathogenesis
Tiziana Parisi1, Blanca Santibanez Ocampo1, Jacob Adelman1
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
JCI Insight
|May 8, 2026
Summary
Age-related blood cell mutations, known as clonal hematopoiesis, alter immune cells and lung tumor microenvironments. However, these changes did not accelerate lung cancer growth in a mouse model.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Age-related blood cell mutations, or clonal hematopoiesis, are increasingly recognized.
- These mutations can influence immune cell function and the tumor microenvironment.
Purpose of the Study:
- To investigate the impact of clonal hematopoiesis on immune cell profiles.
- To examine how clonal hematopoiesis affects lung tumor immune structures.
- To determine if clonal hematopoiesis influences lung cancer growth in a preclinical model.
Main Methods:
- Utilized a genetically engineered mouse model.
- Analyzed age-related blood cell mutations (clonal hematopoiesis).
- Assessed changes in immune cell populations and lung tumor immune microenvironments.
Main Results:
- Clonal hematopoiesis was observed to reshape immune cells.
- Alterations in lung tumor immune structures were identified.
- No significant increase in lung cancer growth was detected in the presence of clonal hematopoiesis.
Conclusions:
- Age-related clonal hematopoiesis can modify the immune landscape within tumors.
- Despite immune alterations, clonal hematopoiesis did not promote lung cancer progression in this model.
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