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Updated: May 9, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Flavonol-mediated modulation of angiogenesis-related microRNAs in breast cancer: a narrative synthesis of current

Dakalo Portia Ramali1, Tania Mmapule Maphoso1, Thanyani Victor Mulaudzi1

  • 1Department of Surgery, Level 7, Bridge E, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Future Oncology (London, England)
|May 8, 2026
PubMed

Insights

Dietary flavonols show potential in breast cancer therapy by modulating angiogenesis-regulating microRNAs (angiomiRs). Further research is needed to validate these findings for clinical applications in precision oncology.

Area of Science:

  • Oncology
  • Molecular Biology
  • Nutritional Science

Background:

  • Angiogenesis is crucial for breast cancer growth and metastasis.
  • Current therapies targeting vascular endothelial growth factor (VEGF) have limited efficacy due to resistance.
  • Angiogenesis-regulating microRNAs (angiomiRs) are key regulators of tumor vascular plasticity and immune evasion.

Purpose of the Study:

  • To review the mechanistic links between dietary flavonols and angiomiR-mediated regulation in breast cancer.
  • To evaluate the therapeutic potential of flavonols in overcoming resistance to anti-angiogenic therapies.
  • To identify gaps in current research for future translational studies.

Main Methods:

  • A narrative review of studies published between 2010-2026.
  • Searches conducted across Google Scholar, PubMed, Scopus, and Web of Science.
  • Synthesis of mechanistic and translational findings on flavonols, angiomiRs, and breast cancer angiogenesis.

Main Results:

  • Flavonols (kaempferol, myricetin, quercetin) exhibit anti-angiogenic activity in preclinical models.
  • Flavonols may influence angiogenesis directly by inhibiting signaling pathways and indirectly via non-coding RNA modulation.
  • Evidence suggests flavonols can impact hypoxia signaling, endothelial activation, and vascular normalization through angiomiR networks.

Conclusions:

  • Flavonol modulation of angiomiRs presents a promising, mechanistically supported strategy against breast cancer angiogenesis.
  • Current evidence is largely preclinical, highlighting a need for experimental validation of specific flavonol-angiomiR interactions.
  • Further translational research is essential to clarify the therapeutic relevance of flavonols in precision oncology for breast cancer.
Keywords:
Breast cancerangiogenesisangiomiRsflavonolsmicroRNAsprecision oncologytherapy resistance

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