Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Role of Hematopoietic Growth Factors

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeted next-generation sequencing for direct drug-resistant tuberculosis detection in sputum samples in Indonesia: an implementation study (2024-25).

The Lancet regional health. Southeast Asia·2026

Same author

Early clearance of Mycobacterium tuberculosis among Indonesian household contacts is not associated with circulating beta-glucan present at the time of exposure.

Tuberculosis (Edinburgh, Scotland)·2026

Same author

Circulating metabolites associated with protection against Mycobacterium tuberculosis infection and inhibition of mycobacterial growth.

Communications biology·2026

Same author

Exploring the Relationship Between Comorbidities and Prolonged Viral Shedding in COVID-19: A Cycle Threshold Value-Based Investigation.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale·2026

Same author

Operational performance of GeneXpert for tuberculosis diagnosis in West Java province, Indonesia: a public health evaluation.

BMC health services research·2026

Same author

Lipid Profile Differences in HIV-Infected Populations With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis.

Chronic diseases and translational medicine·2026

Search research articles

Related Experiment Video

Updated: May 9, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Growth Differentiation Factor-15 Could Predict Decreased Hemoglobin in Tuberculosis Treated With Linezolid-Containing

Amaylia Oehadian¹, Prayudi Santoso², Delita Prihatni³

¹Hematology and Medical Oncology Division, Department of Internal Medicine, Dr. Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

The Clinical Respiratory Journal

|May 8, 2026

Summary

Baseline Growth Differentiation Factor-15 (GDF-15) levels can predict myelosuppression in patients with rifampicin-resistant tuberculosis (RR-TB) treated with linezolid. Higher GDF-15 levels indicate a greater risk of hemoglobin reduction during treatment.

Keywords:

GDF‐15 RR‐TB hemoglobin linezolid

More Related Videos

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Published on: September 20, 2024

Related Experiment Videos

Last Updated: May 9, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Published on: September 20, 2024

Area of Science:

Pharmacology
Hematology
Infectious Diseases

Background:

Linezolid is crucial for treating rifampicin-resistant tuberculosis (RR-TB).
Linezolid treatment can lead to significant hematological toxicities, including myelosuppression, due to mitochondrial dysfunction in hematopoietic stem cells.
Growth Differentiation Factor-15 (GDF-15) is a potential biomarker for this mitochondrial dysfunction.

Purpose of the Study:

To investigate if baseline GDF-15 levels can predict myelosuppression in RR-TB patients receiving linezolid.
To establish a correlation between GDF-15 levels and hematological changes during linezolid therapy.

Main Methods:

A cohort of 97 RR-TB patients treated with linezolid-containing regimens for at least 4 weeks was studied.
Hematological parameters and GDF-15 levels were measured at baseline, week 2, and weeks 4-8 of treatment.
Statistical analyses, including correlation and AUC calculations, were performed to assess the predictive value of GDF-15.

Main Results:

GDF-15 levels significantly increased by week 2 of linezolid treatment (p=0.003).
Myelosuppression, specifically hemoglobin reduction, occurred in 65% of patients by weeks 4-8.
Baseline GDF-15 levels correlated with hemoglobin reduction (r=0.4, p<0.001) and levels >950 pg/mL predicted >25% hemoglobin reduction (AUC 0.756).

Conclusions:

Baseline GDF-15 levels are a significant predictor of myelosuppression, particularly hemoglobin changes, in RR-TB patients on linezolid.
GDF-15 serves as a valuable biomarker for monitoring and managing linezolid-induced hematological toxicity in this population.