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Related Experiment Video

Updated: May 9, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Association Between Serum Matrix Metalloproteinase-3 Levels and Cognitive Function in Patients With Rheumatoid

Masahiro Tada1, Yoshinari Matsumoto2, Tomoyuki Nakamura3

  • 1Department of Orthopedic Surgery, Osaka City General Hospital, Osaka, Japan.

International Journal of Rheumatic Diseases
|May 8, 2026
PubMed
Summary

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...

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Matrix metalloproteinase-3 (MMP-3) levels, but not erythrocyte sedimentation rate (ESR), were linked to cognitive function in rheumatoid arthritis (RA) patients. Higher MMP-3 indicates poorer cognitive performance and increased risk of mild cognitive impairment (MCI) in RA.

Area of Science:

  • Rheumatology
  • Neuroscience
  • Immunology

Background:

  • Cognitive impairment is a significant comorbidity in rheumatoid arthritis (RA).
  • The link between RA-specific inflammatory markers and cognitive function requires further elucidation.
  • Chronic inflammation in RA may contribute to cognitive vulnerability.

Purpose of the Study:

  • To investigate the association between serum matrix metalloproteinase-3 (MMP-3) and erythrocyte sedimentation rate (ESR) with cognitive function in RA patients.
  • To determine if these inflammatory markers predict mild cognitive impairment (MCI) in RA.

Main Methods:

  • Cross-sectional study of 130 RA patients.
  • Cognitive function assessed using the Mini-Mental State Examination (MMSE).
  • Serum MMP-3 and ESR analyzed as inflammatory markers.
Keywords:
cognitionfrailtyinflammationmini‐mental state examinationrheumatoid arthritis

Related Experiment Videos

Last Updated: May 9, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

  • Multivariable regression models used to identify factors associated with MMSE scores and odds of MCI.

    • Main Results:

    • Higher serum MMP-3 levels correlated with lower MMSE scores, independent of demographic factors and frailty.
    • The association between MMP-3 and cognitive function remained significant after adjusting for ESR.
    • ESR was not significantly associated with MMSE scores in fully adjusted models.
    • Elevated MMP-3 levels were associated with increased odds of MCI, particularly in female patients.

    Conclusions:

    • Serum MMP-3 levels are associated with cognitive function and mild cognitive impairment (MCI) in RA patients.
    • ESR is not a significant predictor of cognitive function in this RA cohort.
    • MMP-3 may reflect RA-specific inflammatory activity relevant to cognitive vulnerability, suggesting potential therapeutic targets.