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Itopride as a Potential Drug Against Cancer (Breast and Prostate), by Repurposing Determined Through AI

José Luis Vique-Sánchez1, Ana Brenda Ortega Morales1

  • 1School of Medicine and Nutrition, Autonomous University of Baja California, Mexicali, Baja California, México.

Archiv Der Pharmazie
|May 8, 2026
PubMed

Insights

Artificial intelligence identified Itopride, a drug for dyspepsia, as a potential cancer treatment. In silico and in vitro studies show Itopride has antiproliferative effects against prostate and breast cancer cells.

Area of Science:

  • Oncology
  • Pharmacology
  • Artificial Intelligence in Medicine

Background:

  • Breast and prostate cancer are leading causes of cancer incidence and mortality globally.
  • There is a continuous need for novel therapeutic strategies and drug options to combat cancer.
  • Drug repurposing, accelerated by artificial intelligence (AI), offers a promising avenue for identifying new cancer treatments.

Purpose of the Study:

  • To investigate the potential of the repurposed drug Itopride as an antiproliferative agent against cancer.
  • To explore the efficacy of Itopride as an adjuvant therapy for prostate and breast cancer.

Main Methods:

  • Utilized artificial intelligence (AI) for drug repurposing to identify potential anticancer agents.
  • Conducted in silico (computational) and in vitro (laboratory) assays to evaluate the antiproliferative effects of Itopride.

Main Results:

  • Itopride demonstrated significant cytotoxic and antiproliferative effects in vitro cancer cell cultures.
  • AI-driven drug repurposing identified Itopride as a potential candidate for cancer therapy.

Conclusions:

  • Itopride exhibits potential as an antiproliferative agent and can be considered a potential adjuvant therapy for prostate and breast cancer.
  • The study highlights the successful application of AI and drug repurposing in discovering novel therapeutic applications for existing drugs.
Keywords:
MDA‐MB‐231PC3artificial intelligencedrug repurposingitopride

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