Itopride as a Potential Drug Against Cancer (Breast and Prostate), by Repurposing Determined Through AI

Area of Science:

• Oncology
• Pharmacology
• Artificial Intelligence in Medicine

Background:

• Breast and prostate cancer are leading causes of cancer incidence and mortality globally.
• There is a continuous need for novel therapeutic strategies and drug options to combat cancer.
• Drug repurposing, accelerated by artificial intelligence (AI), offers a promising avenue for identifying new cancer treatments.

Purpose of the Study:

• To investigate the potential of the repurposed drug Itopride as an antiproliferative agent against cancer.
• To explore the efficacy of Itopride as an adjuvant therapy for prostate and breast cancer.

Main Methods:

• Utilized artificial intelligence (AI) for drug repurposing to identify potential anticancer agents.
• Conducted in silico (computational) and in vitro (laboratory) assays to evaluate the antiproliferative effects of Itopride.

Main Results:

• Itopride demonstrated significant cytotoxic and antiproliferative effects in vitro cancer cell cultures.
• AI-driven drug repurposing identified Itopride as a potential candidate for cancer therapy.

Conclusions:

• Itopride exhibits potential as an antiproliferative agent and can be considered a potential adjuvant therapy for prostate and breast cancer.
• The study highlights the successful application of AI and drug repurposing in discovering novel therapeutic applications for existing drugs.