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Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy
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Visualization and Photo-Programming of Chain Entanglements in Hydrogel Networks by Disulfide Exchange.

Yu Sun1,2, Hui Shang1,2, Zhenyi Jiang1,2

  • 1State Key Laboratory of Advanced Marine Materials, Zhejiang Key Laboratory of Extreme-environmental Material Surfaces and Interfaces, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China.

Angewandte Chemie (International Ed. in English)
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PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to visualize and control polymer chain entanglement in hydrogels. This technique uses photo-responsive bonds to lock in topological states, enabling tunable optical and mechanical properties for advanced materials.

Keywords:
chain entanglementdisulfide exchangehydrogelsshape morphingstructural color

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Soft Matter Physics

Background:

  • Polymer chain entanglement is crucial for hydrogel properties but difficult to control spatially.
  • Existing methods lack direct visualization and precise regulation of topological constraints.

Purpose of the Study:

  • To develop a strategy for encoding and visualizing entanglement states in hydrogels.
  • To link microscopic topological constraints to macroscopic material responses.

Main Methods:

  • Introduction of photo-responsive disulfide bonds into a lamellar hydrogel framework.
  • Controlled dehydration to induce temporary topological constraints.
  • UV-triggered disulfide exchange to fix entanglement states.
  • Photomask patterning for spatial control and mapping of topological states.

Main Results:

  • Preserved topological states were visualized through variations in lamellar spacing and color shifts upon reswelling.
  • Two-dimensional mapping of spatial entanglement distribution was achieved using photomask patterning.
  • pH stimulation induced 3D shape morphing in patterned hydrogel regions.

Conclusions:

  • Established a direct link between microscopic topological constraints and macroscopic optical/mechanical responses.
  • Demonstrated a platform for creating hydrogels with spatially defined anisotropy and an interpretable topological readout.
  • Enabled tunable optical and mechanical properties for advanced materials.