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Related Experiment Video

Updated: May 9, 2026

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

Function and Structure Relationships With Inflammation Differ in Two Chronic Suppurative Lung Diseases.

Teresa Fuchs^1,2,3,4, Jacqueline Donovan^1,2,3, Andrew Ives^1,2

¹National Heart & Lung Institute, Imperial College London, London, UK.

Pediatric Pulmonology

|May 8, 2026

Summary

This summary is machine-generated.

In cystic fibrosis (CF) and primary ciliary dyskinesia (PCD), systemic inflammation is higher in CF, while sputum IL-6 is higher in PCD. Sputum IL-6 predicts lung function differently in each disease, being beneficial in CF.

Keywords:

cystic fibrosis inflammation long‐term primary ciliary dyskinesia sputum

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Area of Science:

Pulmonary Medicine
Immunology
Genetics

Background:

Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) share neutrophilic airway inflammation but exhibit distinct clinical phenotypes.
Understanding the differences in inflammatory markers and their correlation with lung disease progression is crucial for patient management.

Purpose of the Study:

To investigate the relationships between pulmonary and systemic inflammatory markers and functional/structural lung disease in CF and PCD.
To identify markers that predict long-term outcomes in both CF and PCD.

Main Methods:

Systemic (CRP, IgG, IL-6, IL-8) and sputum (calprotectin, IL-6, IL-8) inflammatory markers were measured at baseline in 42 patients (21 CF, 21 PCD).
Relationships were analyzed with spirometry, lung clearance index, and computed tomography (CT) scores at baseline and spirometry 10 years later.

Main Results:

Systemic inflammation markers (neutrophils, IL-6, IL-8) were significantly higher in CF patients.
Sputum IL-6 and IL-8 were elevated in PCD patients.
In CF, sputum IL-6 correlated with better CT scores and improved spirometry over 10 years.
Conversely, high sputum IL-6 in PCD was associated with worse lung function after 10 years.

Conclusions:

This study highlights significant differences in functional and structural lung disease between CF and PCD.
Specific inflammatory markers were identified as predictors of long-term outcomes in both diseases.
The paradoxical finding of sputum IL-6 correlating with better lung health in CF warrants further investigation.