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Updated: May 9, 2026
04:36
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
Factors Influencing Intraocular Pressure Elevation During Hemodialysis
Kyunghee Lee1,2, Seungchan Park1, Ekamol Tantisattamo2
1Division of Nephrology, Department of Internal Medicine, Daegu Veterans Health Service Medical Center, Daegu, Republic of South Korea.
Translational Vision Science & Technology
|May 8, 2026
Summary
Intraocular pressure (IOP) increases during hemodialysis (HD), particularly in patients with high serum osmolality. This ocular disequilibrium highlights the need for ophthalmic monitoring in high-risk HD patients.
Area of Science:
- Ophthalmology
- Nephrology
- Physiology
Background:
- Hemodialysis (HD) can induce physiological changes affecting ocular parameters.
- Understanding intraocular pressure (IOP) and ocular perfusion pressure (MOPP) during HD is crucial for patient eye health.
Purpose of the Study:
- To investigate IOP and MOPP fluctuations during maintenance HD.
- To identify clinical and HD-related factors associated with IOP elevation.
Main Methods:
- Prospective, observational study of 56 patients (103 eyes) undergoing HD.
- IOP measured at 5 time points; MOPP calculated. Serum osmolality (PreOsm) collected.
- Generalized estimating equation and ROC analyses used to evaluate IOP changes and predict elevation.
Main Results:
- IOP increased during HD, peaking at 4 hours (17.5 ± 0.5 mm Hg).
- Higher PreOsm (>312 mOsm/kg) correlated with greater IOP increases and elevated risk of >5 mm Hg IOP rise.
- Phakic lens status showed a trend towards association with IOP elevation.
Conclusions:
- Transient intra-dialytic IOP elevation is influenced by serum osmolality.
- Ocular disequilibrium during HD necessitates targeted ophthalmic monitoring for high-risk individuals.
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